Setmelanotide

ImcivreeMetabolic/Weight

Evidence grade

AFDA-approved Rx (labeled use)

Cardiovascular · 0–5 · separate axis

Read first · not dosing instructions

Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.

PurposeMetabolic / Weight

MechanismMC4R agonist restoring signalling in the melanocortin pathway for specific genetic obesity syndromes

EffectsTargets a specific inherited defect in appetite signalling; not a general weight-loss drug

Dosing2-3 mg SC once daily following titration (per prescribing information)

Bottom lineStrongest data when used for its labeled indication under clinician guidance.

Batches on filenone

No tested batches on file.

Read with10

Glucagon Tesamorelin Somatropin Sermorelin CJC-1295 (no DAC)Ipamorelin GHRP-2 GHRP-6 BPC-157 TB-500

Cautions & interactions

Skin hyperpigmentation; injection-site reactions; sexual adverse events including priapism; depression and suicidal ideation reported

Monitor for depression and skin changes; follow the prescribing information.

CV 1 of 5 — Weight reduction in the labelled population is substantial, but no cardiovascular outcomes trials support broader use.