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Somatropin

Human Growth HormoneGH Axis
Evidence grade
AFDA-approved Rx (labeled use)
Cardiovascular · 0–5 · separate axis
1
Read first · not dosing instructions

Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.

PurposeEndocrine
MechanismRecombinant GH for deficiency states
EffectsSignals the GH axis; can affect body composition, fluid retention, and glucose
DosingNo human dose established.
Bottom lineStrongest data when used for its labeled indication under clinician guidance.
Protocols · as published2 sourced
FDA labelGenotropin, adult GH deficiency
RouteSubcutaneous
FrequencyWeekly dose divided into 6 or 7 daily injections
StartingNon-weight-based: about 0.2 mg/day (range 0.15-0.30 mg/day). Weight-based: not more than 0.04 mg/kg/week.
EscalationNon-weight-based: increase every 1-2 months by about 0.1-0.2 mg/day per clinical response and serum IGF-I. Weight-based: may increase at 4-8 week intervals.
TargetPer clinical response and serum IGF-I
MaximumWeight-based: not more than 0.08 mg/kg/week

Adult doses are stated per day (about 0.2 mg/day, non-weight-based) or per week (weight-based); the instruction to divide the weekly dose into 6 or 7 injections sits in the label's general dosing text. Pediatric GHD: 0.16-0.24 mg/kg/week. Other somatropin brands have their own labels. Anti-aging use is not an approved indication, and US law restricts distribution of hGH for unapproved uses.

Community protocol — not clinically establishedCommunity guide
RouteSubcutaneous
FrequencyDaily, 5-7 days/week
Starting1-2 IU daily, SC, empty stomach
Escalation"Start at 1-2 IU and titrate based on IGF-1 levels"
TargetWellness 1-2 IU/day; body recomposition 2-4 IU/day; recovery 2-3 IU/day
Cycle3-6+ months continuous

1 mg somatropin = 3 IU (secondary converter). Community starting doses (about 0.33-0.67 mg) are above the label's adult start (about 0.2 mg).

Batches on file1
24 IUJA-69769 · 2025-0796.13%
Read with10
Cautions & interactions

Edema, joint pain, glucose effects; contraindications in active malignancy; medical supervision required

Can raise glucose; monitor if on diabetes meds; fluid retention may affect BP/CHF; avoid with active malignancy (per clinical guidance).

CV 1 of 5 — No solid direct cardiovascular outcomes evidence; any benefit is indirect or unproven.