PEPTIDE CORTEXThe library
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Sermorelin

research/compoundedGH Axis
Evidence grade
DResearch/compounded/adjunct (no established FDA indication)
Cardiovascular · 0–5 · separate axis
1
Read first · not dosing instructions

Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.

PurposeGH axis
MechanismGHRH analog; stimulates GH release
EffectsSignals the GH axis; can affect body composition, fluid retention, and glucose
DosingNo human dose established.
Bottom linePopular in research/compounding; human safety/benefit not well-established.
Protocols · as published2 sourced
Label — former US label (Geref, withdrawn)Geref, pediatric GH deficiency (as summarised in review)
RouteSubcutaneous
FrequencyOnce daily at bedtime
Starting30 mcg/kg SC once daily at bedtime
EscalationNone
Target30 mcg/kg nightly, prepubertal children with idiopathic GH deficiency

Withdrawn from the US market; no current US label. From a peer-reviewed review of the former labelled regimen, not the label document. Pediatric and weight-based; no adult trial.

Community protocol — not clinically establishedCommunity guide
RouteSubcutaneous
FrequencyNightly, 30-60 minutes before bed, on an empty stomach
Starting100 mcg nightly, weeks 1-2
Escalation200 mcg weeks 3-4; 300 mcg weeks 5-8; 400-500 mcg week 9+ "if response at 300 mcg is not enough"
Target200-300 mcg nightly
Cycle3-6 months at target dose; some use 5 on / 2 off
Batches on filenone

No tested batches on file.

Read with10
Cautions & interactions

Quality variability; endocrine effects; avoid unsupervised use

No well-established interaction profile for non-approved peptides; avoid combining multiple research compounds; discuss meds with clinician.

CV 1 of 5 — No solid direct cardiovascular outcomes evidence; any benefit is indirect or unproven.