Plecanatide

TrulanceGI/Bone/Other

Evidence grade

AFDA-approved Rx (labeled use)

Cardiovascular · 0–5 · separate axis

Read first · not dosing instructions

Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.

PurposeGI

MechanismGuanylate cyclase-C agonist structurally close to uroguanylin; increases intestinal fluid secretion

EffectsSame target as linaclotide with pH-dependent activity

Dosing3 mg orally once daily; 6 mg for IBS-C per prescribing information

Bottom lineStrongest data when used for its labeled indication under clinician guidance.

Batches on filenone

No tested batches on file.

Read with10

Desmopressin (DDAVP)Teriparatide (Forteo)Abaloparatide (Tymlos)CGRP (Calcitonin gene-related peptide)Semaglutide Tirzepatide Liraglutide Exenatide Dulaglutide Pramlintide

Cautions & interactions

Diarrhoea; contraindicated under 6 years of age and in known mechanical obstruction

Severe diarrhoea can affect absorption of other oral medicines and electrolyte balance.

CV 0 of 5 — Minimal systemic absorption; no meaningful cardiovascular signal.