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PEG-MGF
researchMuscle/PerformanceEvidence grade
DResearch/compounded/adjunct (no established FDA indication)
Cardiovascular · 0–5 · separate axis
1
Read first · not dosing instructions
Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.
PurposeMuscle repair / Recovery
MechanismPEGylated (polyethylene glycol-modified) version of Mechano Growth Factor with extended half-life, providing sustained satellite cell activation and muscle repair signaling
EffectsExtended-release satellite cell activation; promotes muscle hypertrophy; systemic muscle repair signaling; longer half-life than native MGF
DosingNo human dose established.
Bottom lineMore practical than native MGF due to PEGylation extending half-life, but still lacks human clinical evidence.
Protocols · as published1 sourced
Community protocol — not clinically establishedCommunity guide
RouteIntramuscular into trained muscle (sources disagree; some say SC)
Frequency2-3x per week on training days, within 1-2 h post-workout
Starting200 mcg, 2x/week (the source's "beginner")
Escalation300 mcg 2-3x/week ("intermediate"); 400 mcg 3x/week ("advanced")
Target200-400 mcg per injection, 2-3x/week
Cycle4-6 weeks on, 4-6 weeks off
WhereLocal IM preferred ('maximizes the concentration at the site where satellite cells are being activated').
No human dose-finding trial.
Sourcepeptidewiki.co ↗
Cautions & interactions
Not FDA-approved; limited human data; injection site reactions; potential for uncontrolled growth signaling
Caution with insulin (hypoglycemia); no well-established interaction profile; discuss with clinician.
CV 1 of 5 — No cardiovascular outcomes data.