Linaclotide

LinzessGI/Bone/Other

Evidence grade

AFDA-approved Rx (labeled use)

Cardiovascular · 0–5 · separate axis

Read first · not dosing instructions

Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.

PurposeGI

MechanismGuanylate cyclase-C agonist; increases intestinal fluid secretion and accelerates transit

EffectsActs locally in the gut with minimal systemic absorption

Dosing72-290 mcg orally once daily depending on indication

Bottom lineStrongest data when used for its labeled indication under clinician guidance.

Batches on filenone

No tested batches on file.

Read with10

Desmopressin (DDAVP)Teriparatide (Forteo)Abaloparatide (Tymlos)CGRP (Calcitonin gene-related peptide)Semaglutide Tirzepatide Liraglutide Exenatide Dulaglutide Pramlintide

Cautions & interactions

Diarrhoea is the most common adverse effect; contraindicated under 2 years of age

Severe diarrhoea can affect absorption of other oral medicines and electrolyte balance.

CV 0 of 5 — Minimal systemic absorption; no meaningful cardiovascular signal.