Leuprolide

Lupron DepotSexual Health

Evidence grade

AFDA-approved Rx (labeled use)

Cardiovascular · 0–5 · separate axis

Read first · not dosing instructions

Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.

PurposeReproductive axis

MechanismGnRH agonist; after an initial flare it downregulates the pituitary and suppresses sex-hormone production

EffectsShuts the reproductive axis down rather than stimulating it; the opposite direction to gonadorelin

Dosing7.5 mg IM monthly (depot); other depot strengths per prescribing information

Bottom lineStrongest data when used for its labeled indication under clinician guidance.

Batches on filenone

No tested batches on file.

Read with10

Oxytocin Melanotan II Semaglutide Tirzepatide Liraglutide Exenatide Dulaglutide Pramlintide Cagrilintide Retatrutide

Cautions & interactions

Initial testosterone flare; bone-density loss with prolonged use; hot flushes; mood changes

Additive effects with other hormone therapies; may prolong QT; review concurrent QT-prolonging drugs.

CV 2 of 5 — Androgen deprivation is associated with adverse cardiometabolic changes over time; monitor lipids and glucose.