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L-Carnitine

levocarnitine, CarnitorNot a peptide · nutrientMetabolic/Weight

Not a peptide — an amino-acid derivative. Listed because it is commonly discussed alongside them.

Evidence grade
AFDA-approved Rx (labeled use)
Cardiovascular · 0–5 · separate axis
2
Read first · not dosing instructions

Educational and research reference only. Not medical advice, not a recommendation, and not dosing instructions for any person. Figures are reported from the cited source and may be wrong or out of date. Research peptides are not approved for human use. Adults 18+. Consult a licensed physician before any decision about your health.

PurposeMetabolic / Energy
MechanismTransports long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation.
EffectsCorrects primary and secondary carnitine deficiency, its labelled indication. Marketed far more widely for fat metabolism and exercise performance.
DosingThe FDA-approved oral dose for carnitine deficiency is 990 mg two or three times daily using 330 mg tablets; oral solution is 1–3 g/day for a 50 kg patient, started at 1 g/day and titrated against tolerance.
Bottom lineApproved and effective for deficiency. For everything else, the chronic-dosing TMAO question is unresolved and worth taking seriously.
Batches on filenone

No tested batches on file.

Read with

The library records no pairings for this entry.

Cautions & interactions

Nausea, stomach upset, and a fishy body odour at higher doses. The cardiovascular picture is genuinely unsettled — see CV notes before using it long term.

No major drug interactions at labelled doses. The clinically relevant interaction is with the gut microbiome, which converts carnitine to TMAO.

CV 2 of 5 — Cuts both ways, and the catalog does not resolve it. Gut bacteria convert L-carnitine to TMAO, an independent dose-dependent cardiovascular risk marker, and chronic oral dosing drives marked TMAO elevation; one randomised trial reported atherosclerosis progression in metabolic syndrome. Against that, meta-analysis in impaired glucose tolerance and diabetes shows improvement in several cardiovascular risk factors, and carnitine has recognised cardioprotective effects on inflammation and cardiomyocyte oxidative stress. Short-term marker improvement and long-term atherogenic signal are not the same question.